Making Vinyl Ethers

A stereospecific and stereoselective copper promoted coupling of vinyl pinacol boronate esters and alcohols allows the synthesis of enol ethers in very good yields is compatible with various functional groups and occurs at room temperature.

Making vinyl ethers.

The reaction is catalyzed by ni and cu is involved in the transmetalation process. Making vinyl are the go to b2b events for the physical media industry covering everything from recording and preparation to final distribution. 16 hydroalkoxylation of alkynes has been a central access to vinyl ethers with reppe being the pioneer of that. A convenient and efficient protocol for the cross coupling of phenols and vinyl halides by a unique ni cu catalytic system provides an easy access to a library of aryl vinyl and aryl styrenyl ethers.

Vinyl ethers are a highly relevant moiety for organic synthesis allowing a rich follow up chemistry. Lett 2014 16 1040 1043. Vinyl ethers undergo homopolymerization via a cationic mechanism. Vinyl ethers undergo radical initiated copolymerization in the presence of specific monomers such as maleates fumarates and acrylics.

They are increasingly used in radiation curing systems because of a lower toxicity profile than the commonly used acrylic monomers. 15 as a scaffold of interest many protocols for vinyl ether synthesis have been developed. It is also important that r is a good radical leaving group. 8 21 227 228 the mechanism for chain transfer is shown in scheme 9 for the case of α benzyloxystyrene 15 the driving force for fragmentation is provided by formation of a strong carbonyl double bond.

Vinyl ethers 1 x ch 2 a o can be very effective addition fragmentation chain transfer agents.